MBR Health conducts investigator-initiated regenerative medicine research led by Dr Zane Sherif, supported by our senior radiographers, sonographers and clinical research team. Our research investigates the application of biologic regenerative therapies, including platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC), across a broad range of clinical conditions, with a focus on comprehensive diagnosis, precision delivery, protocol optimisation and objective measurement of clinical outcomes.
Our work is grounded in real patient case studies across multiple domains, forming the foundation for larger prospective research programs.
MBR Health’s regenerative medicine research is organised across seven clinical domains, each supported by case study documentation and ongoing protocol development.
The regenerative medicine research programs described on this page are investigator-initiated research activities conducted at MBR Health. These programs are exploratory in nature and do not represent standard or established clinical treatments. Biologic therapies including platelet-rich plasma and other regenerative applications investigated at MBR Health are not approved by the Therapeutic Goods Administration for the specific indications described, and are offered within a research framework only.
Participation is subject to appropriate clinical assessment, eligibility criteria and informed consent. MBR Health does not guarantee specific outcomes from any regenerative medicine research program. We encourage all patients to speak with their GP or specialist before enquiring about research participation.
MBR Health has documented case study outcomes investigating PRP and/or BMAC for a range of orthopaedic conditions, such as knee osteoarthritis or tendinopathies, with image-guided delivery under ultrasound or spectral CT ensuring precise target selection and reproducible dosing.
Our case study work explores the potential of high-dose, high-frequency PRP as biologic adjuncts in non-surgical anterior cruciate ligament repair (ACL), investigating ligament healing response, return to function and objective imaging assessment of structural change following treatment.
MBR Health has documented case study outcomes investigating image-guided PRP for chronic low back pain, with a focus on target selection, dosing protocols, safety profiling and measured clinical response across discogenic and facetogenic pain pathways.
Our case study work investigates image-guided PRP for peripheral neuropathy, exploring the potential of biologic therapy to support nerve regeneration and function. Neurography provides objective imaging assessment of nerve structure and response to treatment.
MBR Health has conducted case study investigations into nebulised PRP for chronic lung conditions. This is a novel and emerging application of biologic therapy being approached with rigorous attention to safety profiling, dosing and clinical outcome documentation.
Our case study work investigates PRP for painful bladder syndrome, exploring the potential of biologic therapy to support tissue repair and symptom relief in a condition with limited conventional treatment options.
Across all clinical domains, MBR Health conducts dedicated research into PRP protocol optimisation, investigating preparation methods, concentration, activation, dosing and delivery techniques to maximise therapeutic consistency and clinical outcomes.
Spectral CT-guided HA Injection Regenerative medicine research at MBR Health is underpinned by our comprehensive diagnostic imaging infrastructure. Diagnosis and target selection are informed by advanced MRI neurography and non-invasive discography, providing the diagnostic precision required for accurate patient selection and treatment planning.
Biologic therapies are delivered under image guidance using ultrasound and spectral CT, ensuring precise target selection and reproducible dosing. MBR Health utilises a dedicated platelet counter to quantify platelet concentration in every PRP preparation, addressing one of the most significant limitations in the existing PRP literature and ensuring every treatment delivers a known and reproducible dose. Treatment response is monitored through serial diagnostic imaging, with quantitative MRI available where clinically indicated.
Serial MRI of Non-surgical mediated ACL Repair (Sherif et. al, 2025) Biologic therapies represent a fundamental shift in how degenerative, inflammatory and complex chronic conditions are approached, investigating the potential to restore tissue function and offer patients alternatives to surgical intervention or long-term pharmaceutical management. MBR Health’s regenerative medicine research is distinctive in three important ways:
Dr Zane Sherif, Specialist Radiologist Dr Zane Sherif leads MBR Health’s regenerative medicine research program, bringing deep clinical expertise in image-guided biologic therapy delivery across all our research domains. Dr Zane is driven by a commitment to answering genuine clinical questions through rigorous case study documentation, protocol optimisation and objective outcome measurement.
Supported by our Senior Radiographers,
Sonographers and Clinical Research Team.
Our regenerative medicine research is relevant to a
broad range of clinicians, researchers and patients.
Our orthopaedic and ACL research investigates image-guided PRP and BMAC as biologic adjuncts to conventional management. We welcome referrals and research collaborations from orthopaedic surgeons and sports medicine physicians with an interest in regenerative approaches.
Our research is relevant to physiotherapists working with patients who have not responded to conventional rehabilitation or who are seeking to optimise recovery outcomes. We welcome referrals and research collaborations from sports and musculoskeletal physiotherapists with an interest in biologic adjuncts to conservative management.
Our painful bladder syndrome research investigates PRP for a condition with limited conventional treatment options. We welcome referrals and research collaborations from urologists and pelvic health specialists.
Our neuropathy, low back pain and craniocervical instability research explores image-guided PRP across complex pain and nerve conditions. We welcome collaboration with neurologists, pain specialists and spine surgeons interested in biologic therapy as an adjunct to conventional management.
Health welcomes collaboration with clinician-scientists and higher-degree researchers seeking to build on our case study foundations across any of our regenerative medicine research domains. Access to our research-grade imaging infrastructure, platelet quantification capability and image-guided delivery expertise provides a strong platform for investigator-initiated research.
Focused on rehabilitation adjuncts, conservative management and patients not responding to conventional therapy.
If you are living with a condition that has not responded to conventional treatment, or are interested in exploring image-guided regenerative medicine as part of your care, we welcome your enquiry. Our regenerative medicine research program investigates platelet-rich plasma and novel biological therapies across a range of musculoskeletal, neurological, gynaecological and other conditions through rigorous case study documentation and protocol development.
Please contact our research team to discuss whether exploratory regenerative medicine pathways may be appropriate for your situation. We recommend speaking with your treating clinician in the first instance to ensure any regenerative medicine pathway is considered within the full context of your care.
Meeting the highest standards of laboratory and imaging accreditation in Australia.
All R&D staff hold active Good Clinical Practice certification ensuring regulatory compliance across every study.
Working with leading global imaging technology partners on next-generation spectral CT development.
Across oncology, opportunistic health assessment, breast imaging and dose reduction programs.
Every protocol developed at MBR Health is validated through direct clinical application and real-world patient care.
MBR Health has contributed to the peer-reviewed literature through published case reports and clinical updates, advancing the current understanding of diagnostic imaging and regenerative medicine across our active research programs.